The small molecule NSM00191 specifically represses the TNF-α/NF-кB axis in foot and ankle rheumatoid arthritis
نویسندگان
چکیده
منابع مشابه
Rheumatoid Arthritis of the Foot and Ankle.
Rheumatoid arthritis of the foot and ankle can be a debilitating problem, particularly for patients who have undergone successful hip or knee arthroplasty. Optimal medical management, use of orthotic devices, and surgical intervention are essential components of patient care. Forefoot involvement with hallux valgus and lesser metatarsophalangeal joint subluxation and dislocation are the most co...
متن کاملNew molecules for the treatment of rheumatoid arthritis Novel small molecule therapeutics in rheumatoid arthritis
A new wave of emerging therapies for the treatment of autoimmune and inflammatory diseases is under development. These therapies interrupt intracellular signalling through kinase inhibition. By interrupting one or more kinases it is possible to modulate the function of cellular structures such as surface receptors, signalling proteins and transcription of nuclear proteins and thus influence the...
متن کاملFoot and ankle kinematics in rheumatoid arthritis: influence of foot and ankle joint and leg tendon pathologies.
OBJECTIVE From early onset of the disease, patients with rheumatoid arthritis (RA) experience walking impairments. Pathologic effects of RA on foot and ankle structures have been studied clinically, but little is known as to how they relate to kinematic changes during gait. The aim of this study was to explore the relationship between clinically observed pathologies of foot and ankle joints and...
متن کاملClinical practice guidelines for the foot and ankle in rheumatoid arthritis: a critical appraisal
BACKGROUND Clinical practice guidelines are recommendations systematically developed to assist clinical decision-making and inform healthcare. In current rheumatoid arthritis (RA) guidelines, management of the foot and ankle is under-represented and the quality of recommendation is uncertain. This study aimed to identify and critically appraise clinical practice guidelines for foot and ankle ma...
متن کاملTOPIC REVIEW: Diagnostic work-up of early rheumatoid arthritis in the foot and ankle patient
Rheumatoid arthritis is a chronic, progressive disease that affects the synovial membranes of joints, and leads to bone and cartilage destruction of both small and large joints in the upper and lower extremities. Foot and ankle specialists may be the first providers to recognize symptoms at their earliest stages. As first line providers a good understanding of the disease and its classification...
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ژورنال
عنوان ژورنال: International Journal of Biological Sciences
سال: 2018
ISSN: 1449-2288
DOI: 10.7150/ijbs.24232